Regulation of Vascular Smooth Muscle Cell Proliferation

Differential Regulation of Vascular Smooth Muscle and Endothelial Cell Proliferation

37 cAMP inhibits proliferation in most cell types triggering different and sometimes opposing 38 molecular pathways. p85α (PI3K regulatory subunit) is phosphorylated by cAMP/PKA in certain 39 cell lineages but its effects on vascular smooth muscle cells (VSMCs) and endothelial cells (ECs) 40 are unknown. In the present study we evaluated: i) the role of p85α in the integration of 41 cAMP/PKA-de...

Hypoxic Pulmonary Vascular Smooth Muscle Cell Proliferation

The effect of adrenomedullin and proadrenomedullin N- terminal 20 peptide on angiotensin II induced vascular smooth muscle cell proliferation

Objective(s): The study aimed to investigate the effects of adrenomedullin (ADM) and proadrenomedullin N- terminal 20 peptide (PAMP) on angiotensin II (AngII)-stimulated proliferation in vascular smooth muscle cells (VSMCs). Materials and Methods: Thoracic aorta was obtained from Wistar rats and VSMCs were isolated from aorta tissues and then cultured. In vitro cultured VSMCs were stimulated w...

Mechanisms of telomerase induction during vascular smooth muscle cell proliferation.

Telomeres are primarily controlled by a highly specialized DNA polymerase termed telomerase. Recent studies have demonstrated that introduction of the telomerase catalytic component (TERT) into telomerase-negative cells activates telomerase and extends cell life span, whereas mice lacking telomerase activity revealed impaired cell proliferation in some organs as well as reduced tumorigenesis. T...

Bilirubin: a natural inhibitor of vascular smooth muscle cell proliferation.

BACKGROUND Bilirubin, a natural product of heme catabolism by heme oxygenases, was considered a toxic waste product until 1987, when its antioxidant potential was recognized. On the basis of observations that oxidative stress is a potent trigger in vascular proliferative responses, that heme oxygenase-1 is antiatherogenic, and that several studies now show that individuals with high-normal or s...